The founder of the company, engineer Christian Liisberg, laid the foundation for Intellix in 1986 in connection with the Chernobyl disaster. Liisberg, while employed at the Risoe Danish National research centre headed a group of scientists in studying neural networks and their use for monitoring multiple processes at nuclear plants. Their research led to intense attention to a specific technology - the N-tuple Classifier which led to the development of a proprietary technology called Self Optimizing Universal Learner (SOUL) targeted at image recognition.

Liisberg followed by developeding a decision support system called ZEUS in 1990 whose aim was to permit users to access expert knowledge. Although the system only enjoyed limited take-up, it was the incubator to transform ZEUS into a product called Case Agent (whose aim was to make informed and consistent decisions for local governments).

Liisberg soon recognized the vast potential of the SOUL technology, after winning the unofficial world championships in pattern recognition (in the finals with his IBM laptop with a 386 processor beating a supercomputer from Thinking Machines with 56,000 processors), and started his own company Chr. Liisberg A/S in 1992. The neural networks of the mid-1990’s were no doubt akin to a “technology in search of a solution”, they were the forerunner of today’s applications. The beauty of the technology was incremental learning and unlearning meaning the ability to “learn” and “unlearn” in real time, without having to re-train/teach the model every time.

In 1997, the company name changed to Intellix - the mission was “delivering software to capture, store and communicate knowledge” – tenants still true today.

In 1998, the concept of knowledge domains was born and Intellix released its first decision support system called the Knowman Designer. Consequently, the SOUL Analyser became the Knowman Analyser. Intellix then introduced the Knowman Knowledge Server to make knowledge domains accessible through the Internet. This product portfolio laid the foundations for the development of today’s Intellix’ product suite.

What has characterized Intellix as genuinely unique is the fact that the products were designed and built 'bottom up' and decisions about the look-and-feel of the product were made on a 'need to' basis. In fact, when the development team embarked on the software creation itself, they had no pre-conceived notions regarding the final product, liberated from the traditional development constraints; they thought “out of the box.” The basic and overriding goal was to create a knowledge delivery tool where anybody with minor computing training could store knowledge for later use and improve on decision-making.

In 1998, a major Swiss insurer adopted Intellix’ solution to report claims over the Internet. A Danish financial institution adopted an Intellix solution for its help desk in 1998, and in 1999, research on a server prototype began, targeting integration to back-end open IT frameworks.

From 2000 to 2001, Intellix matured and deployed that framework allowing them to fulfill key customer requirements. New development processes were introduced and overall R&D was strengthened. Intellix also won “Reader’s Choice PC World Product”, further evidence of the product’s applicability. Jyske Bank, Denmark’s 2nd largest bank chose Intellix software for building and maintaining best practices in investment advising for its clients and used by the banks 1,200 advisors all over Denmark, and at the Banks foreign branches.

The same year Dial Insurance, Sweden's first online insurance company, chose Intellix for selling insurance and managing claims online. The year after, Intellix won a large IT project for automating claims handling at IF Insurance (Scandinavia’s largest non-life insurer), in competition with the Nasdaq listed Pega Systems.

In 2002, in competition with iLog/IBM, Intellix won an enterprise business into the process industry of shrink-wrapped software to Eastman Chemical, a $6 billion global business and one of the top 10 specialty chemicals companies in the world. Eastman did a thorough evaluation of competing products on the market, and implemented several pilots of varying purpose and scope, before making the final purchase decision.

In 2005 Jyske Bank expanded the use of Intellix to debt management and introduced the Debt Advisor – an advising system used by 300 corporate advisors aimed at small and mid-sized companies for managing their debt with advanced financial instruments (futures, swaps etc.) The same year Intellix ventured into the healthcare arena after discussions with professors at the Icelandic National University Hospital, Landspitalet and Intellix ehf, Iceland was established.                        

In 2007 the Icelandic Biotech company Expeda chose Intellix for developing decision support tools for diagnosis and treatment recommendations for osteoporosis and a variety of auto immune diseases.

In 2009 Expeda's first product was launched – the Expeda's Osteoporosis Risk Advisor.

By combining data from clinical research and patient specific information about family history, medical information and life style factors the tool analyzes each risk factor individually and collectively and in an interactive and motivational manner present the patients risk for a major osteoporotic fracture during the next 10 years and inform about what risk group patient is in (normal, medium, high) and in comparison to his peers in the same age group (z-score).

The Osteoporosis Risk Calculator will aid the GP in the diagnosis and treatment of the patient. Whether the patient be sent to a bone density scan (DXA), do life style changes, start drug treatment, or be sent to specialist for further investigation. According to Expeda the Intellix system shortens the time for diagnosis and treatment up to 6 months and thus will decrease the risk of fractures with 40-70% in patients lifetime.

In 2010 Intellix leveraged the results obtained in Iceland towards the healthcare community in the US and participated with Microsoft at the IDC Healthcare Conference in Savannah, GA. As a result in depth discussions were initiated between Intellix and MSFT Healthcare Solutions Group and mutual business cases outlined within the US Healthcare industry.

The same year Intellix was approached by SAP for investigating options were Intellix products and/or core technology could improve SAP’s offerings within Business Rules Management (BRM) and Business Process Management (BPM). 

During 2011 - 2013 several large organizations in bank, insurance and healthcare chose Intellix as their provider of decision intelligence solutions for automating , most important among them were DNB, (Norway), Sjova (Iceland) and Bispebjerg-Frederiksberg Hospital (Denmark). During the same period Expeda's Osteoporis Risk Calculator developed by Intellix was integrated with the Icelandic National Electronic Health Record System and made available to 1,000 medical doctors.

In 2014 Intellix and James Lakes (CEO and former director of Strategy and Business Development at Microsoft US Healthcare Solutions Group) established the joint venture -Intellix Checklists,Inc.- with Johns Hopkins University Hospital, Dr. Peter Pronovost and Dr. Bradford Winters to jointly develop and market intelligent medical checklists.